Faculty Profile

Name: Monica Valentovic
Title: Professor
Office: Pharmacology/SOM
Phone: 304-696-7332
Email: valentov@marshall.edu
Expert:
 

Achievements
Research Based:
	Abstracts: M.A. Valentovic, J.G. Ball and B.A. Rogers. Comparison of cephaloridine in vitro renal toxicity between normoglycemic and diabetic rats. Toxicologist 30:306-307, 1996. S.-K. Hong, D.K. Anestis, L.D. Dial, M.A. Valentovic, J.G. Ball and G.O. Rankin. Effect of ascorbic acid and acivicin on 4-amino-2,6-dichlorophenol (ADCP)-induced nephrotoxicity in the Fischer 344 rat. Toxicologist 30:306, 1996. N.M. Hawco, M.A. Valentovic, and G.O. Rankin. Effect of hepatic S9 fraction coincubation with renal cortical slices on N-(3,5-dichlorophenol)succinimide (NDPS) and NDPS metabolite nephrotoxicity. Toxicologist 30:308, 1996. G.O. Rankin, S.K. Hong, D.K. Anestis, C.C. Skaggs, J.B. Ball, and M.A. Valentovic. N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in GUNN rats. Toxicologist 36:145, 1997. D.K. Anestis, S.K. Hong, J.G. Ball, M.A. Valentovic, and G.O. Rankin. Dose dependent effect of sodium sulfate on N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity. Toxicologist 36:146, 1997 S.K. Hong, D.K. Anestis, J.B. Ball, M.A. Valentovic, and G.O. Rankin. A role for leukotrienes in N-(3,5-dichloro-phenyl)succinimide (NDPS) metabolite nephrotoxicity in Fischer 344 rats. Toxicologist 36:146, 1997. M.A. Valentovic, J.G. Ball, S.K. Hong, and G.O. Rankin. In vitro nephrotoxicity of 2- and 4-chloroaniline: comparisons with 4-amino-3-chlorophenol, 2-amino-5-chlorophenol and aminophenols. Toxicologist 36:146, 1997. J.B. Ball, R.C. Harmon, and M.A. Valentovic. Differences in renal cephaloridine toxicity and accumulation following insulin pretreatment of diabetic rats. Toxicologist 36:148, 1997. S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, and G.O. Rankin. NDPS and NDPS metabolite nephrotoxicity in Wistar rats. Toxicologist 42:376, 1998. M.A. Valentovic, J.G. Ball, and R.C. Harmon. 3,4-Dichloroaniline toxicity in renal cortical slices from Fischer 344 rats. Toxicologist 42:376, 1998. M.A. Valentovic, J.G. Ball and G.O. Rankin. 2-amino-5-chlorophenol toxicity in rat renal cortical slices: effect of antioxidants. Toxicologist 43:28, 1999. G.O. Rankin, S.K. Hong, D.K. Anestis, J.G. Ball and M.A. Valentovic. Phenobarbital potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5- dichlorophenylsuccinamic acid (2-NDHSA) nephrotoxicity in male but not female Fischer 344 rats. Toxicologist 43:28, 1999. S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic and G.O. Rankin. Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5- dichlorophenylsuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats. Toxicologist 43:28, 1999. M.A. Valentovic, J.G. Ball and G.O. Rankin. 2-Amino-4,5-dichlorophenol (2A45CP) toxicity in renal cortical slices from Fischer 344 rats. Toxicologist 54:404, 2000. G.O. Rankin, S.K. Hong, D.K. Anestis, J.G. Ball and M.A. Valentovic. Attenuation of 4-amino-2,6-dichlorophenol nephrotoxicity in renal cortical slices by ascorbate, aminooxyacetic acid, indomethacin and gluathione. Toxicologist 54:404, 2000. S.L. Miles, S.K. Hong, O. Noe, D.K. Anestis, M.A. Valentovic, J.G. Ball and G.O. Rankin. Evidence for nephrotoxic sulfate conjugates of N-(3,5-dichlorophenyl)succinimide metabolites. Toxicologist 54:503, 2000. M.A. Valentovic, J.G. Ball. 3,4-Dichlorophenylhydroxylamine induced alterations in rat renal cortical slices: The effect of antioxidants and sulfhydryl agents. Presented at Contemporary Concepts in Toxicology: Mechanisms of Nephrotoxicity and Nephrocarcinogenicity April 15-18 Martha’s Vineyard, MA. J. Minigh and M.A. Valentovic. Effects of myoglobin on renal cortical slices from Fischer 344 rats. Toxicologist 60:309, 2001. MA. Valentovic, J.G. Ball, N.F. Alejandro and K.S. Ramos. Renal effects of Benzo(a)pyrene in diabetic rats. Toxicologist 60:310, 2001. S.L. Miles, D.K. Anestis, J.G. Ball, M.A. Valentovic and G.O. Rankin. Effects of N-(3,5-dichlrophenyl)succinimide (NDPS) metabolites on adenosine nucleotide levels in isolated rat renal cortical epithelial cells. Toxicologist 60:310, 2001. G.O. Rankin, D.K. Anestis, S.K. Hong, J.G. Ball and M.A. Valentovic. Effect of diuresis on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in Fischer 344 rats. FASEB J. 15 (4), A236 (212.1), 2001.
	Publications (peer reviewed): M.A. Valentovic, J.G. Ball and B.A. Rogers. Comparison of cephaloridine renal accumulation and urinary excretion between normoglycemic and diabetic animals. Toxicology 108:93-99, 1996. G.O. Rankin, K.W. Beers, D.W. Nicoll, D.K. Anestis, S.K. Hong, J.L. Hubbard, J.G. Ball, M.A. Valentovic, and P.I. Brown. Nephrotoxic potential of 2-amino-5-chlorophenol and 4-amino-3-chlorophenol: Comparisons with 2- and 4- chloroaniline and 2- and 4- aminophenol. Toxicology 108:109-123, 1996. S.K. Hong, D.K. Anestis, N.M. Hawco, M.A. Valentovic, P.I. Brown and G.O. Rankin. Nephrotoxicity of N-(3-bromophenyl)-2-hydroxy-succinimide: role of halogen groups in the nephrotoxic potential of N-(halophenyl)succinimides. Toxicology 110:17-25, 1996. S.K. Hong, M.A. Valentovic, D.K. Anestis, J.G. Ball, P.I. Brown and G.O. Rankin. Nephrotoxicity of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol in the Fischer 344 rat. Toxicology 110:47-58, 1996. M.A. Valentovic, J.G. Ball, S.K. Hong, B.A. Rogers, M.K. Meadows, R.C. Harmon and G.O. Rankin. In vitro toxicity of 2- and 4-chloroaniline: comparisons with 4-amino-3- chlorophenol, 2-amino-5-chlorophenol and aminophenol. Toxicology In Vitro 10:713-720, 1996. M.A. Valentovic, T. Yahia, J.G. Ball, S.K. Hong and G.O. Rankin. 3,4-Dichloroaniline acute toxicity in Fischer 344 rats. Toxicology 124; 125-134, 1997. M.A. Valentovic, B.A. Rogers, M.K. Meadows, J.T. Conner, E. Williams, S.K. Hong and G.O. Rankin. Characterization of methemoglobin formation induced by 3,5-dichloroaniline, 4-amino-2,6-dichlorophenol and 3,5-dichlorophenyl-hydroxylamine Toxicology 118:23-36, 1997. M.A. Valentovic, J.G. Ball, B.A. Rogers, M.K. Meadows, R.C. Harmon and J. Moles. Cephaloridine in vitro toxicity and accumulation in renal slices from normoglycemic and diabetic rats. Fund. Appl. Toxicol. 38: 184-190, 1997. S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, P.I. Brown and G.O. Rankin. 4-Amino-2,6-dichlorophenol (ADCP) nephrotoxicity in the Fischer 344 rat: Protection by ascorbic acid, AT-125 and aminooxyacetic acid. Toxicol. Appl. Pharmacol. 147: 115-125, 1997. M.A. Valentovic and J.G. Ball. 2-Aminophenol and 4-aminophenol toxicity in renal slices from Sprague Dawley and Fischer 344 rats. J Toxicology Environ. Health. 55(3):225-240, 1998. S.K. Hong, D.K. Anestis, M.A. Valentovic, J.G. Ball, P.I. Brown, R.T. Wang and G.O.Rankin. Gender differences in acute N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (NDHSA) nephrotoxicity in Fischer 344 rats. J Toxicol Environ Health 54(8):613-32, 1998. D.G. Lister, J. Carl III, J.H. Morgan, D.A. Denning, M.Valentovic, B. Trent, B.L. Weaver. Pediatric all-terrain vehicle trauma: a 5 year statewide experience. J Pediatric Surg. 33(7):1081-3, 1998. S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, P.I. Brown and G.O. Rankin. Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats. Toxicology 132:43-55, 1999. J.L. Hubbard, O. Noe II, M. Egermayer, S.K. Hong, D.K. Anestis, M.A. Valentovic, J.G. Ball and G.O. Rankin. Nephrotoxic potential of N-(3,5-dichloro-4-fluorophenyl) succinimide in Fischer 344 rats: Comparison with N-(3,4,5-trichlorphenyl)succinimide. Toxicology 132:119-125, 1999. S.K. Hong, D.K. Anestis, J.G. Ball, M. A. Valentovic, P.I. Brown and G.O. Rankin. Effect of sulfation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats. J. Toxicol. Environ. Health Part A 57:47-62, 1999. M.A. Valentovic, M.K. Meadows, R.C. Harmon, J.G. Ball, S. Stohl, S.K. Hong and G.O. Rankin. 2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: Effects of antioxidants and sulfhydryl agents. Toxicol. Appl. Pharmacol. 161: 1-9, 1999. S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, P.I. Brown and G.O. Rankin. Sodium sulfate potentiates N-(3,4-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat. Toxicology 138(3): 165-74, 1999. M.A. Valentovic, J.G. Ball, S. Stoll and G.O. Rankin. 3,4-Dichlorophenylhydroxylamine cytotoxicity in renal cortical slices from Fischer 344 rats. Toxicology 162(3): 149-156, 2001. S.K. Hong, D.K. Anestis, M.A. Valentovic, J.G. Ball, P.I. Brown and G.O. Rankin. Gender differences in the potentiation of N-(3,5-dichlorophenyl)sucinimide metabolite nephrotoxicity by Phenobarbital. J Toxicol Environ Health 64(3): 241-256, 2001. G.O. Rankin, H. Sun, D.K. Anestis, O. Noe, J.G. Ball, M.A. Valentovic, P.I. Brown and J. L. Hubbard. Role of stereochemistry in N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity. Toxicology 168: 241-250, 2001. G.O. Rankin, S.K. Hong, D.K. Anestis, T.T. Henderson, J.G. Ball, M.A. Valentovic and P.I. Brown. Effect of three N-acetylamino acids on N-(3,5-dichlorophenyl)succinimide (NDPS)and NDPS metabolite nephrotoxicity in Fischer 344 rats. J. Toxicol. Environ Health J Toxicol. Environ. Health 65:539-556, 2002. S.K. Hong, D.K. Anestis, J.G. Ball, M.A. Valentovic, G.O. Rankin. In vitro nephrotoxicity induced by chloronitrobenzenes in renal cortical slices from Fischer 344 rats. 129:133-141, 2002. M.A. Valentovic, J.G. Ball, H. Sun and G.O. Rankin. Characterization of 2-amino-4,5-dichlorophenol (2A45CP) In Vitro Toxicity in Renal Cortical Slices from Male Fischer 344 rats. Toxicology 172 (2): 113-123, 2002.
Professional/Community Based Service:
	Society of Toxicology (SOT): SOT, In Vitro Specialty Section, Councilor 1998-2001. SOT, In Vitro Specialty Section, Vice President Elect, 2000-2001. SOT, In Vitro Specialty Section, Vice President, 2001-present. SOT New Investigator Forum, 1990. In Vitro Specialty Section, Judge for Outstanding Graduate Student Abstract 1999, 2000, 2001. Mechanisms Specialty Section, Judge for Outstanding Graduate. Student Manuscript, 2000.

Return to Search Page