Faculty Profile

Name: Gary Rankin
Title: Professor & Chair
Office: Pharmacology/School of Medicine
Phone: 304-696-7313
Email: rankin@marshall.edu
Expert:
 

Achievements
Research Based:
	Abstracts: Hong, S. K., Anestis, D. K., Skaggs, C. C., Ball, J. G., & Valentovic, M. A. (1997). N-(3,5-Dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in Gunn rats [Abstract]. Toxicologist, 36(1), 145. Hong, S. K., Anestis, D. K., Ball, J. G., Valentovic, M. A., & Rankin, G. O. (1997). A role for leukotrienes in N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in Fischer 344 rats [Abstract]. Toxicologist, 36(1), 146. Anestis, D. K., Hong, S. K., Ball, J. G., Valentovic, M. A., & Rankin, G. O. (1997). Dose dependent effects of sodium sulfate on N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity [Abstract]. Toxicologist, 36(1), 146. Valentovic, M. A., Ball, J. G., Hong, S. K., & Rankin, G. O. (1997). In vitro nephrotoxicity of 2- and 4-chloroaniline. Comparisons with 4-amino-3-chlorophenol, 2-amino-5-chlorophenol andaminophenols [Abstract]. Toxicologist, 36(1), 146. Hong, S. K., Anestis, D. K., Brown, P. I., & Wang, R. T. (1998). Gender differences in N-(3,5-dichlorophenyl)succinimide metabolite nephrotoxicity [Abstract]. Toxicologist, 42(1-S), 376. Hong, S. K., Anestis, D. K., Ball, J. G., Valentovic, M. A., & Rankin, G. O. (1998). N-(3,5-Dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity in Wistar rats [Abstract]. Toxicologist, 42, (1-S), 376. Hong, S. K., & Anestis, D. K. (1998). Effect of N-acetylamino acids on N-(3,5-dichlorophenyl)succinimide (NDPS) and NDPS metabolite nephrotoxicity [Abstract]. FASEB Journal, 12, (5), A767. Hong, S. K., Anestis, D. K., & Rankin, G. O. (1998). 4-Amino-2,6-dichlorophenol (ADCP) toxicity in renal cortical slices, Protection by ascorbic acid and glutathione [Abstract]. FASEB Journal,12(5), A767. Hong, S. K., & Anestis, D. K., Ball, J. G., & Valentovic, M .A. (1999). Phenobarbital potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in male but not female Fischer 344 rats [Abstract]. Toxicologist, 48(1), 28-29. Hong, S. K., Anestis, D. K., Ball, J. G., Valentovic, M. A. & Rankin, G. O. (1999). Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats [Abstract]. Toxicologist, 48(1), 29. Valentovic, M. A., Ball, J. G., & Rankin, G. O. (1999). 2-Amino-5-chlorophenol (2A5CP) toxicity in rat renal cortical slices: Effects of antioxidants [Abstract]. Toxicologist, 48 (1), 28.
	Book Chapters: Harvison, P. J. & Rankin, G. O. (1996). Biotransformation and membrane transport in nephrotoxicity. In. L. Lash &R. Zalups, (Eds.), Methods in Renal Toxicology (pp. 331-335). Boca Raton, FL: CRC Press. (1997). Succinimides. In R. s. Goldstein, (Ed.), Comprehensive Toxicology, Volume 7, Renal Toxicology (pp. 665-675). Headington Hills, Oxford, UK:Pergamon. (1998). Target organ—kidney. In P. Wexler, et al., (eds.), Encyclopedia of Toxicology (pp. 198-225). San Diego, CA: Academic Press.
	Funded Grants: (1996). Health, Safety and Environmental Protocol. U.S. Navy.co-investigator, $60,155. (1992, August 1 - 1998, July 31). Chemical-induced nephrotoxicity: Succinimides. NIH (NIDDK) DK31210 principal investigator, $608,698. (1998, April 1–2001, March 31). Chemical-induced nephrotoxicity: Succinimides. NIH (NIDDK), DK31210, principal investigator, $635,128.
	Publications: Shih, H., & Rankin, G. O. (1996). A convenient one-pot synthesis of N-arylmalonamic acid via in-situ generation of malonyl monoacyl chloride. Synthetic Communications, 26, (4), 833-836. Beers, K. W., Nicoll, D.W., Anestis, D. K., Hong, S. K., Hubbard, J.L., Ball, J.G., Valentovic, M.A., & Brown, P. I. (1996). Nephrotoxic potential of 2-amino-5-chlorophenol and 4-amino-3-chlorophenol: Comparisons with 2- and 4- chloroaniline and 2- and 4-aminophenol. Toxicology, 108, 109-123. Hong, S. K., Anestis, D. K., Hawco, N.M., Valentovic, M. A., Brown, P. I., & Rankin, G. O. (1996). Nephrotoxicity of N-(3-bromophenyl)-2-hydroxysuccinimide:Role of halogen groups in the nephrotoxic potential of N-(halophenyl)succinimides. Toxicology, 110, 17-25. Hong, S. K., Valentovic, M. A., Anestis, D. K., Ball, J. G., Brown, P. I. & Rankin, G. O. (1996). Nephrotoxicity of 4-amino-2-chlorophenol and 2-amino-4-chlorophenol in the Fischer 344 rat. Toxicolog,y 110, 47-58. Valentovic, M. A., Ball, J. G., Hong, S. K., Harmon, R. C., & Rankin, G. O. (1996). In vitro toxicity of 2- and 4-chloroaniline:Comparison with 4-amino-3-chlorophenol, 2-amino-5-chlorophenol and aminophenols. Toxicology In Vitro 10, 713-720. Beers, K. W., Teets, V. J., Nicoll, D. W., & Anestis, D. K. (1997). Buthionine sulfoximine (BSO) and N-(3,5-dichlorophenyl)succinimide nephrotoxicity:Temporal aspects of BSO administration and BSO effects on renal transport systems. Toxicology, 117, 207-217. Valentovic, M. A., Rogers, B. A., Meadows, M. K., Conner, J. T., Williams, E., Hong, S. K., & Rankin, G. O. (1997). Characterization of methemoglobin formation induced by 3,5-dichloroaniline, 4-amino-2,6-dichlorophenol and 3,5-dichlorophenylhydroxylamine. Toxicolology, 118, 23-36. Hong, S. K., Valentovic, M. A., Beers, K. W., Anestis, D. K., Nicoll, D. W., Ball, J. G., & Brown, P. I. (1997). Effects of sodium sulfate on acute N-(3,5-dichlorophenyl) succinimide (NDPS) nephrotoxicity in the Fischer 344 rat. Toxicology, 123, 1-13. Hong, S. K., Anestis, D. K., Ball, J. G., Valentovic, M. A., Brown, P. I., & Rankin, G. O. (1997). 4-Amino-2,6-dichlorophenol (ADCP) nephrotoxicity in the Fischer 344 rat: Protection by ascorbic acid, AT-125 and aminooxyacetic acid. Toxicology and Applied Pharmacology, 147, 115-125. Valentovic, M. A., Yahia, T., Ball, J. G., Hong,S. K. & Rankin, G. O. (1997). 3,4-Dichloroaniline acute toxicity in Fischer 344 rats. Toxicology, 124, 125-134. Hong, S. K., Anestis, D. K., Valentovic, M. A., Ball, J. G., Brown, P. I., Wang, R. T., & Rankin, G. O. (1998). Gender differences in acute N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in Fischer 344 rats. Journal of Toxicology and Environmental Health, Part A, 54, 613-632. Hong, S. K., & Rankin, G. O. (1998). Biotransformation of 2-chloroaniline in the Fischer 344 rat: Identification of urinary metabolites. Xenobiotica, 28, (10), 985-994. Dial, L. D., Anestis, D. K., Kennedy, S. R., & Rankin, G .O. (1998). Tissue distribution, subcellular localization and covalent binding of 2-chloroaniline and 4-chloroaniline in Fischer 344 rats. Toxicology, 131, 109-119. Hong, S. K., Anestis, D. K., Skaggs, C., Brown, P. I. & Rankin, G. O. (1999). The role of glucuronidation in N-(3,5-dichlorophenyl)succinimide (NDPS) nephrotoxicity: Nephrotoxic potential of NDPS and NDPS metabolites in Gunn, Wistar and Fischer 344 rats. Journal of Toxicology and Environmental Health, Part A, 154, 170-180. Hong, S. K., Anestis, D. K., Ball, J. G., Valentovic, M. A., Brown, P. I., & . Rankin, G. O. (1999). Effect of glucuronidation substrates/inhibitors on N-(3,5-dichlorophenyl)succinimide nephrotoxicity in Fischer 344 rats. Toxicology, 132, 43-55. Hubbard, J. L., Noe, II, O., Egermayer, M., Hong, S. K., Anestis, D. K., Valentovic, M. A., Ball, J. G., & Rankin, G .O. (1999). Nephrotoxic potential of N-(3,5-dichloro-4-fluorophenyl)succinimide in Fischer 344 rats: Comparison with N-(3,4,5-trichlorophenyl) succinimide. Toxicology, 132, 119-125. Hong, S.K., Anestis, D. K., Ball, J. G., Valentovic, M. A., Brown, P. I. & Rankin, G. O. (1999). Effect of sulfation substrates/inhibitors on N-(3,5-dichlorophenyl) succinimide nephrotoxicity in Fischer 344 rats. Journal of Toxicology and Environmental Health, Part A, 57, 47-62. Valentovic, M. , Meadows, M. K., Harmon, R .C., Ball, J. G., Hong, S. K., & Rankin, G. O. (1999). 2-Amino-5-chlorophenol toxicity in renal cortical slices from Fischer 344 rats: Effect of antitoxidants and sulfhydryl agents. Toxicology and Applied Pharmacology, 161, 1-9. Hong, S. K., Anestis, D. K., Ball, J .G., Valentovic, M. A., Brown, P. I. & Rankin, G. O. (1999). Sodium sulfate potentiates N-(3,5-dichlorophenyl)-2-hydroxysuccinimide (NDHS) and N-(3,5-dichlorophenyl)-2-hydroxysuccinamic acid (2-NDHSA) nephrotoxicity in the Fischer 344 rat. Toxicology, 138, 165-174

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