Xie Research Lab
Research Interests
Our research interests center on the synthesis, surface modification, self-assembly of materials at nanometer scale to address problems in the field of biomaterials, regenerative medicine and drug/gene delivery. Our research programs are built upon interdisciplinary subjects including materials science, biology and engineering. We will develop novel, smart biomaterials with well-controlled composition, structure and functional properties. We will employ analytical tools in materials science, biology and medicine to characterize these biomaterials as either scaffolds or drug/gene carriers.
Members of the Xie research group include, from left, David Edward Bartlett, Dr. Jingwei Xie, Dr. Jiang Jiang and Dr. Bing Ma.
Techniques
Electrospinning
Electrohydrodynamic atomization (electrospray)
Micro/nano fabrication
Chemical synthesis
Journal Covers
Selected Publications
Xie, J., Ma, B. and Michael, P. L. (2012), Fabrication of Novel 3D Nanofiber Scaffolds with Anisotropic Property and Regular Pores and Their Potential Applications. Advanced Healthcare Materials. doi: 10.1002/adhm.201200100.
Xie J*, Ma B, Michael PL, Shuler FD. Fabrication of nanofiber scaffolds with gradations in fiber organization and their potential applications. Macromolecular Biosciences. 2012 in press.
Xie J*, Michael PL, Zhong S, Ma B, MacEwan MR, Lim CT. Mussel inspired protein-mediated surface modification to electrospun fibers and their potential biomedical applications. Journal of Biomedical Materials Research Part A, 100A: 929-938, 2012. (This work is featured on the Global Medical Discovery website.)
Xie J*, Blough ER, Wang CH. Submicron bioactive glass tubes for bone tissue engineering. Acta Biomaterialia, 8: 811-819, 2012.
Xie J, Liu W, MacEwan MR, Yeh YC, Thomopoulos S and Xia Y. Nanofiber membranes with controllable microwells and structural cues and their use in forming cell microarrays and neuronal networks. Small, 2011, 7, 293-297. (This article was featured on the cover.)
Xie J, MacEwan MR, Ray WZ, Liu W, Siewe DY and Xia Y. Radially aligned, electrospun nanofibers as dural substitutes for wound closure and tissue regeneration applications. ACS Nano, 2010, 4, 5027-5036. (This article was featured on the cover, highlighted in Chemical& Engineering News and Spotlight section on Nanowerk web).
Xie J, Lei C, Hu Y, Gay GK, Jamali NHB and Wang CH. Nanoparticulate formulations for paclitaxel delivery across MDCK cell monolayer. Current Pharm. Design, 2010, 16, 2331-2340. (This article was highlighted on the cover.)
Xie J, Li X, Lipner J, Wolfe C, Schwartz AG, Thomopoulos S and Xia Y. Aligned-to-random” nanofiber scaffolds for mimicking the structure of tendon-to-bone insertion site. Nanoscale, 2010, 2, 923-926.
Xie J, MacEwan MR, Schwartz GA and Xia Y. Electrospun nanofibers for neural tissue engineering. Nanoscale,2010, 2, 35-44. (In February 2010, this article was amongst the top ten accessed articles from the online version of Nanoscale, http://www.rsc.org/Publishing/Journals/nr/top10.asp.)
Xie J, Macewan MR, Willerth SM, Li X, Sakiyama-Elbert SE and Xia Y. Neurite outgrowth on nanofiber scaffolds with different structures, orders, and surface properties. ACS Nano. 2009, 3, 1151-1159. (This work was highlighted on the cover, and featured on Audio/podcast http://pubs.acs.org/page/ancac3/audio/index.html).
Li X, Xie J, Lipner J, Yuan X, Thomopoulos S and Xia Y. Nanofiber scaffolds with gradations in mineral content for mimicking the tendon-to-bone insertion site. Nano Lett., 2009, 9, 2763-2768. (This work was featured in Chemical & Engineering News, on the Nanotechweb, and in the November issue of Discover magazine, page 13)
Xie J, Willerth SM, Li X, Macewan MR, Rader A, Sakiyama-Elbert SE and Xia Y. The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages. Biomaterials, 2009, 30, 354-362. (Part of the work was highlighted in Nature Materials, 2008, 7, 760).
Xie J, Li X and Xia Y. Putting electrospun nanofibers to work for biomedical research. Macromol. Rapid Comm., 2008, 29, 1775-1792. (Highlighted on the cover, most accessed articles 2/2009–1/2010, highlighted in Materials Views 2008, November A5).
Xie J, Marijinissen JCM and Wang CH. Microparticles developed by electrohydrodynamic atomization for the local delivery of anticancer drug to treat C6 glioma in vitro. Biomaterials, 2006, 27, 3321-3332.
Xie J and Wang CH. Self-assembled biodegradable nanoparticles developed by direct dialysis for the delivery of paclitaxel. Pharm. Res., 2005, 22, 2079-2090.
Patents
Lumino
Leuthardt E, Bayly P, Brody D, Dacey R, Genin G, Holtzman D, Lusis E, Moran D, Pappu R, Xie J, Zipfel G, Fok S, Garrison D. US patent pending.
Nanofiber dural substitute and nanofiber dural patch
MacEwan MR, Xie J, Ray WZ, Xia, Y. US Patent Application Serial No. 61/35572.
Nanofiber scaffolds for delivery of heparin binding growth factors
Thomopoulos S, Sakiyama-Elbert S, Silva M, Gelberman R, Xia Y, Schwartz A, Xie J. US patent pending.
People
Jingwei Xie, Ph.D.
Senior Scientist
Ph.D. in ChBE, National University of Singapore, 2007 (with Professor Chi-Hwa Wang)
Postdoctoral Fellow in BME, Washington University in St. Louis, 2007-2010 (with Professor Younan Xia)
Bing Ma, M.D., Ph.D.
Postdoctoral Fellow
Ph.D. in Wound Repair, Third Military Medical University in Chongqing, China, 2005
M.Sc. in Wound Repair, Third Military Medical University, 2001
B.Sc. in Medicine, Third Military Medical University, 1992
Jiang Jiang, Ph.D.
Postdoctoral Fellow
Ph.D., Hefei Institutes of Physical Science, Chinese Academy of Sciences, 2009 (with Professor Zengliang Yu)
B.S., Department of Physics, Shandong University
David Edward Bartlett
Undergraduate Student
B.S., Biological Science, Marshall University, 2013 (expected)